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http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15156251&dopt=Abstract
Variations in plasma free radicals with topical
aescin + essential phospholipids gel in venous hypertension: new
clinical data.
Ricci A,
Ruffini I,
Cesarone MR,
Cornelli U,
Corsi M,
Belcaro G,
Ippolito E,
Dugall M.
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G.
D'Annunzio University, Italy.
The aim of this study was the evaluation of the effects of Aescin +
essential phospholipids (AEPL) gel on plasma free radicals (PFRs). In
this study, ten patients with venous hypertension, no ulcerations or
infections, venous microangiopathy, and varicose veins were treated with
topical AEPL applied in a standard protocol. AEPL was applied for 2
weeks, three times daily at the same skin region (perimalleolar internal
region at defined distance from the medial malleolus and from the
anterior edge of the tibia). In subjects with venous hypertension, PFR
values were higher than 420 Carr units. After treatment, the values of
PRF decreased to almost normal as an effect of the massage with AEPL
gel. The decrease in value was observed in all treatment subjects. A
ranking system indicates that the AEPL preparation is active in all
subjects who have venous microangiopathy. The decrease in PFR value was
greater than 30% in all treatment subjects (p < 0.05). The decrease in
PFR can be considered an important indication of an improvement in skin
perfusion, which protects the skin from deterioration and eventually
from venous ulcerations. The evaluation of PFR is an important new
physiologic parameter that can be associated with other noninvasive
tests to study the microcirculation and its evolution and improvement
with systemic or topical medical treatment.
Publication Types:
PMID: 15156251 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15156251&dopt=Abstract
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