Pharmaceutical name:

英文药名：

Fructus Gardeniae Jasminoidis

Biological name:

拉丁名：

Gardenia florida, L.

Gardenia jasminoides Ellis

Pron. in Japanese:

日語發音：

山梔 子sanshishi﹔ 山梔子 kuchinashi or 梔子 shishi

Pron. in Korean:

韓語發音：

ch'icha

Pron. in Cantonese:

粤語發音：

saan1 zi1 zi2

Other Names:

別名﹕

mu dan 木丹，yue tao 越桃，xian zhi 鲜支。

Common Name:

英文名：

gardenia fruit

Distribution:

分佈﹕

Hunan, Jiangxi, Hubei, Zhejiang, Fujian provinces of China.

湖南 ﹐江西﹐ 湖北﹐浙江﹐福建等省。

Properties (characteristics)﹕

性味﹕

bitter, cold, non-toxic.

苦﹐ 寒﹐ 無 毒。

Channels (meridians) entered:

歸經﹕

heart, liver, lung, stomach, triple warmer (san jiao)

心﹐ 肝﹐肺﹐ 胃﹐三焦。

Actions & Indications:

主治﹕

being used as antipyretic, insomnia and  irritability, high fever with delusion.

infection with fever with vomiting blood, nose bleeding, blood in urine, swollen red eyes, boils.

jaundice due to liver or gall bladder infection.

1.熱病發熱，心煩不眠，或高熱狂躁，神昏譫 語。
2.熱毒實火引起之吐血，鼻衂，尿血，目赤腫痛及瘡瘍腫毒等症。
3.肝膽濕熱所致之發黃症。

Medical Function:

药理：

1. effects on digestive system: it can lower the increased liver enzyme AST on animal caused by total ligation of bile duct. The ingredient, geniposide, can inhibit the secretion of stomach acid. It can promote the secretion of pancreattic enzyme and promote bile secretion..

2. effects on circulation system

3. effects on CNS: the ursolic acid can inhibit the CNS

4.  antibiotic effect: it can inhibit Staphylococcus aureus, Neisseria meningitidis, Neisseria catarrhal. The decoction can kill adult Schistosoma leptospirosis. The water of extract in vitro can inhibit a variety of skin fungi.

5. anti-inflammatory: The ethanol extract and also the water extract of zhi zi, ethyl acetate portion and geniposide have a certain anti-inflammatory and can heal soft tissue injury. Ointment made of the extract can accelerate the healing of soft tissue.

6. toxicity effects: acute hepatotoxicity of geniposide at high doses was likely to be linked to oxidative stress, while geniposide at normal dose of 24.3 mg kg(-1) or less did not cause hepatotoxicity even in the repeated dosing study in rats.[0]

1. 對消化系统作用：對肝 功能的影响: 能降低對结扎總胆管动物的AST升高有降低作用【1】. 其京尼平甙能抑制胃酸之分泌。它能促進胰腺分泌。有利胆作用。

2. 對循環系统作用

3. 對神經經中樞作 用：熊果酸具有明顯的中樞抑制作用

4. 抗菌 作用：梔子對金黃色葡萄球菌、腦膜炎雙球菌、卡他球菌等有抑制作用, 煎劑有殺死鉤端螺旋體及血吸虫成虫的作用, 水浸液在體外對多種皮膚真菌有 抑制作用．

5. 抗炎作用: 梔子乙醇提取物, 水提取物, 乙酸乙酯部分和京尼平甙有抗炎和治療軟組織損傷的作用．其提取物制成油膏, 可加速軟組 織的愈合．

6. 毒性：梔子苷高劑量可能引起急性肝中毒，可能與氧化應激，梔子苷在正常劑量為24.3毫克/公斤（-1）以下時並沒有引起肝毒性，即使在大鼠研究中，重複給藥研。梔子一般對人無毒，但對動物如馬，狗，貓會有毒。[0]

Chemical ingredients:

化學成份：

Dosage:

每日用 量﹕

3 - 12 g per day

3 ~ 12 克。

Samples of formulae:

處方舉例：

long dan xie gan wan 龍膽瀉肝丸

long dan xie gan tang 龍膽瀉肝湯

Modern Research:

现代研究：

to be loaded

Cautions:

禁忌：

contraindication in loose stool or loss of appetite due to pixu (spleen deficient) with yangxu (yang deficient).

Geniposide caused diarrhea in laboratory mice.

梔子甙 曾經使試驗室小鼠腹瀉。 脾虛兼陽 虛而便溏者忌用。