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圖片來源﹕台北市農會

Present Day Applications:

P.reynoutria Makino;Reynoutia Japonica Houtt

別名﹕

川七.班杖.酸杖.黃藥子.川筋龍.大蟲杖

性味﹕

味微苦﹐性平

歸經﹕

liver, spleen

入肝、脾二經。

藥理﹕

Medical Functions:

1. anti viral

2. anti leptospirosis

3. anti fungal

4. relaxes the bronchial smooth muscles, expels phlegm, and suppresses asthma and cough

5. lower blood pressure and lipids

6. stops bleeding in external injuries

7. inhibits pain

8. astringent

9. anti inflammatory

10.  antibiotic, like:  Pseudomonas aeruginosa，Staphylococcus aureaus，Moraxella (Branhamella), catarrhalis，Streptococcal，Escherichia coli.

藥理﹕

1。抗病毒

2。抗鉤端螺旋體 (leptospirosis)、

3。抗真菌
4。鬆弛支氣管平滑肌，而達鎮咳平喘, 袪痰止咳
5。降血壓及降血脂之作用

6。對外傷出血有明顯的止血作用

7。鎮痛

8。收斂

9。消炎

10。抗菌﹕如綠膿桿菌 Pseudomonas aeruginosa，金黃色葡萄球菌Staphylococcus aureaus， 卡他球菌 Moraxella (Branhamella) catarrhalis，鏈球菌 Streptococcal，大腸桿菌Escherichia coli,等

For jaundice, gall bladder stones, blood stasis with menses stoppage, yeast infection, rheumatoid arthritis, physical injuries from impacts, inflammation of the bronchi, lobar pneumonia, poisonous snake bites, scalding injuries, acute hepatitis, urinary tract infection, boils, stoppage of menses due to heat in the blood, breast cancer, menopausal bleeding disorder.

黃疸，膽結石，經閉瘀阻, 帶下，風濕痛，跌扑損傷，支氣管炎，大葉性肺炎, 毒蛇咬傷，燙火傷，急性肝炎，尿道感染，瘡癤腫毒，血熱經閉，乳癰，崩漏。

根和根莖含游離蔥昆及恩昆苷，主要為大黃素(emodin)、大黃素甲醚(physcion)[1,3]，大黃酚(chrysophanol)[1,2],恩苷A(anthraglycoside A)即大黃素甲醚8-o-β-D-葡萄糖苷(physcion-8-O-β-D-glucoside)[4]，恩苷B(anthraglycoside B)即大黃素8-o-β-D-葡萄糖苷(emodin-8-O-β-D-glucoside)[3,4]，迷人醇(fallacinol)、6-羥基蘆薈大黃素(citreorosein)、大黃素-8-甲醚(questin)、6-羥基蘆薈大黃素-8-甲醚(questinol)[5]等。還含醇類化合物：白黎蘆醇(resveratrol)即是3,4'.5-三羥基醇(3,4',5-trihydroxystilbene)、虎杖苷(polydatin)即白黎蘆醇3-O-β-D-葡萄糖苷(resveratrol-3-O-β-D-glucoside)[3,6],又含原兒茶酸(protocatechuicacid)、右旋兒茶精(catechin)、2，5-二甲基-7-羥基色酮(2,5-dimethyl-7-hydroxychromone)、7-羥基-4-甲氧基-5-甲基香豆精(7-hydroxyl-4-methoxy-5-methylcoumarin)、2-甲氧基-6-乙醚基-7-甲基胡桃昆(2-methoxy-6-acetyl-7-methyljuglone)、決明恩酮-8-葡萄糖苷(torachrysone-8-O-D-glucoside)[5],3-谷甾醇葡萄糖苷(B-sitosterolglucoside)[3]以及葡萄糖(glucose)、鼠李糖(rhamnose)[1]，多糖 polysaccharides [7]，氨基酸(amino acid)12.99%和  銅 copper、鐵 iron、錳 manganese、鋅 zinc、鉀potassium 及鉀鹽 potassium salt [8]等。

用量﹕

每日10～20公克；濃縮中藥：每日0.5～2.0公克。

(1) For vaginal yeast infection: hu zhang 100g, water 1500 cc. Simmer down to 1000 cc. Strain. Cold down to bath water temperature. Use for sitting bath. Use 10 to 15 minutes, once a day. 7 days is one therapy cycle. Treated 30 patients. All healed.

(1) 真菌性陰道炎：虎杖根100g，加水1500ml，煎取1000ml，過濾，待溫，坐浴10～15分鐘，每日1次，7日為1療程，治療30例，全部臨床治愈。

not to use during pregnancy.

孕婦忌服。

中国药理学与毒理学杂誌电子版

虎杖有效成分3,4′,5-三羟基芪-3-β-D-葡萄糖苷的研究进展

骆苏芳　金行中　叶建锋　张佩文

第一军医大学基础部毒理学教研室　广州　510515

【摘要】總 结了虎杖有效成分3,4′,5-三羟基芪-3-β-D-葡萄糖苷(虎杖晶Ⅳ) 近10年来的研究，评价了虎杖晶Ⅳ在防止动脉内皮损伤性血栓形成，改善休克微循环，提高休克大鼠存活率，减轻缺血再灌注，自由基，内毒素等造成的组织器官损伤，降血脂及抗脂质过氧化等方面的作用。提示虎杖晶Ⅳ可能成为治疗血栓性疾病及改善休克微循环等方面一个有特色的新药。

Advances in research on 3,4′,5-trihydrostilbene-3-β-D-glucoside,an effective component from Polygonum cuspidatum Sieb. et Zucc

Abstract

  The advances in recent 10 years in research on 3,4′,5-trihydrostilbene-3-β-D-glucoside (polydatin), a effective component from Polygonum cuspidatum Sieb. et Zucc., were summarized in this paper. The actions of polydatin, such as preventing thrombosis from arterial endothelial damage, improving microcirculation and increasing survival rate of shocked rats, alleviating tissueorgan damage induced by ischemia-reperfusion, oxygen free radical and endotoxin, decreasing hyperlipemia, suppressing lipid peroxide and so on were evaluated. The review displays the pharmacologic base of polydatin in treatment of thrombotic diseases and improvement of microcirculation in shock, which enable polydatin to become a new characteristic drug.