Present Day Applications:

现代應用：

preventing thrombosis from arterial endothelial damage

防止血管 內皮損傷所造成的血栓症。

Pharmaceutical name:

英 文药名：

Biological name:

拉 丁學名：

Polygonum cuspidatum Sieb. et Zucc.

Polygonum reynoutria Makino;

Reynoutia Japonica Houtt

Pron. in Japanese:

日 語發音：

Pron. in Korean:

韓 語發音：

Pron. in Cantonese:

粤 語發音：

Common Name:

英 文名：

Other Names:

別 名﹕

川七.班杖.酸杖.黃藥子.川 筋龍.大蟲杖

Distribution:

分 佈：

分佈於全中國。主產於江蘇、浙江、安徽、廣東、廣西、四川、貴州等省。

Properties (characteristics):

性 味﹕

slightly bitter, neutral, slightly toxic

味微苦 ，性平，有小毒。

Channels (meridians) entered:

歸經﹕

liver, spleen

入肝 ﹐脾二經。

藥理﹕

Medical Functions:

1. anti viral

2. anti leptospirosis

3. anti fungal

4. relaxes the bronchial smooth muscles, expels phlegm, and suppresses asthma and cough

5. lower blood pressure and lipids

6. stops bleeding in external injuries

7. inhibits pain

8. astringent

9. anti inflammatory

10.  antibiotic, like:  Pseudomonas aeruginosa，Staphylococcus aureaus，Moraxella (Branhamella), catarrhalis，Streptococcal，Escherichia coli.

藥理﹕

1。抗病毒

2。抗鉤端螺旋體 (leptospirosis)﹐

3。抗真菌
4。鬆 弛支氣管平滑肌，而達 鎮咳平喘, 袪痰止咳
5。降血壓 及降血脂之作用

6。對外傷出血有明顯的止血作用

7。鎮痛

8。收斂

9。消炎

10。抗菌﹕如 綠膿桿菌 Pseudomonas aeruginosa， 金黃色葡萄球 菌Staphylococcus aureaus， 卡他球菌 Moraxella (Branhamella) catarrhalis， 鏈球菌 Streptococcal， 大腸桿菌Escherichia coli,等

For jaundice, gall bladder stones, blood stasis with menses stoppage, yeast infection, rheumatoid arthritis, physical injuries from impacts, inflammation of the bronchi, lobar pneumonia, poisonous snake bites, scalding injuries, acute hepatitis, urinary tract infection, boils, stoppage of menses due to heat in the blood, breast cancer, menopausal bleeding disorder.

黃疸，膽結石，經閉瘀阻, 帶下， 風濕痛，跌扑損傷 ，支氣管炎，大葉性肺炎, 毒蛇咬傷，燙火傷，急性肝炎，尿道感染，瘡癤腫毒，血 熱經閉，乳 癰 ，崩漏。

根和根莖含游離蔥昆及恩昆貳， 主要為

用量﹕

每日10～20公 克；濃縮中藥：每日0.5～2.0公 克。

處方舉例：

(1) For vaginal yeast infection: hu zhang 100g, water 1500 cc. Simmer down to 1000 cc. Strain. Cold down to bath water temperature. Use for sitting bath. Use 10 to 15 minutes, once a day. 7 days is one therapy cycle. Treated 30 patients. All healed.

(1) 真菌性陰道炎：虎杖根100g，加水1500ml，煎取1000ml， 過濾，待溫，坐浴10～15分鐘，每日1次，7日為1療程 ，治療30例，全部臨床治愈。

现代研究：

禁忌：

not to use during pregnancy.

Large dosages and/or long term usage can be toxic to kidneys.

大劑量或長期服用可能對 腎臟有毒。

孕婦忌服。

中國藥理 學 與毒 理學雜 誌電子版

虎杖有效成分3,4′,5-三羟基芪-3-β-D-葡 萄糖貳的研究進展

骆蘇芳　金行中　葉建锋　張佩文

第一軍醫大學基礎部毒理學教研室　廣州　510515

【摘要】總結了虎杖有效成分3,4′,5-三羟基芪-3-β-D-葡萄糖貳(虎杖晶Ⅳ) 近10年來的研究，評 價了虎杖晶Ⅳ在防止動脉内皮損傷 性血栓形成，改善休克微循環，提高休克大鼠存活率，減輕缺血再灌注，自由基，内毒素等造成的組織器官損傷，降血脂 及抗脂質過氧化等方面的作用。 提示虎杖晶Ⅳ可能成為治療血栓性疾病及改善休克微循環等方面一個有特色的新藥。

Advances in research on 3,4′,5-trihydrostilbene-3-β-D-glucoside,an effective component from Polygonum cuspidatum Sieb. et Zucc

Abstract

  The advances in recent 10 years in research on 3,4′,5-trihydrostilbene-3-β-D-glucoside (polydatin), a effective component from Polygonum cuspidatum Sieb. et Zucc., were summarized in this paper. The actions of polydatin, such as preventing thrombosis from arterial endothelial damage, improving microcirculation and increasing survival rate of shocked rats, alleviating tissueorgan damage induced by ischemia-reperfusion, oxygen free radical and endotoxin, decreasing hyperlipemia, suppressing lipid peroxide and so on were evaluated. The review displays the pharmacologic base of polydatin in treatment of thrombotic diseases and improvement of microcirculation in shock, which enable polydatin to become a new characteristic drug.