| she tui 蛇蛻 (in English and Chinese 中英文) Translated into English by: Joe Hing kwok Chu 朱興國編 譯 Pharmaceutical name: 英文藥名﹕ | Periostracum serpentis | Zoological name of source materials: 拉丁動物學名﹕ | Elaphe taeniura Copa (黑眉錦蛇) Elaphe carinata Günther (錦蛇) Zaocys dhumnades Cantor (烏梢蛇) Natrix piscator Schneider (漁游蛇) | Pron. in Japanese: 日語發音﹕ | shatai; dai sei | Pron. in Korean: 韓語發音﹕ | sase | Pron. in Cantonese:: 粵音﹕ | se4 teoi3 | Other Names: 別名﹕ | long zi yi 龍子衣，she fu 蛇符，long zi dan yi 龍子單衣，gong pi 弓皮，long pi 龍皮，long dan yi 龍 單衣，she jun 蛇筋，she fu 蛇附，she pi 蛇皮，long zi pi 龍子皮，she tui pi 蛇蛻皮，she ke 蛇 殼，she tui 蛇退，long yi 龍衣，qing long yi 青龍衣，chang chong pi 長虫皮，bai ling yi 白龍衣 | Common Name: 英文名﹕ | snake slough | Distribution: 產地﹕ | Mainly produced in Zhejiang, Guangxi, Sichuan, Jiangsu, Fujian, Anhui, Shaanxi, Yunnan provinces. 主產浙江，廣西，四川，江蘇，福建，安徽 ，陝西，雲南等地。 | Properties (characteristics)﹕ 性味﹕ | sweet, salty, neutral. 甘，鹹，平。 | Channels (meridians) entered: 歸經﹕ | liver, spleen. 肝，脾。 | | Medical functions: 藥理﹕ | Medical functions: 1. The anti-inflammatory effect: Indomethacin (indomethacin, IDM), Phenylbutazone, PB were used as control drugs. Male rats (200-300g body weight) and Dd strain male mice (20g) were used. The feed and water were fed ad libitum. Experimental results show that: 1.1. Acute toxicity test, no significant toxicity. Method preparation: using snake slough boiled water extract, freeze-dried to produce yellow-brown powder. The yield was 5.4%.
1.2: The inhibition of leukocyte mobility effect: Using extract of 20mg/kg intravenously, the inhibition rate was approximately 51.1% (P <0.01). The inhibition of leukocyte mobility of using daily oral administration of 200mg/kg for 5 days: the inhibition rate was 33.7% (P <0.02 ). .2. Paw edema inhibition effect: inhibition of edema caused by carrageenan, using oral administering of the herb extract was ineffective. But, using 50mg/kg subcutaneous injection and 20mg/kg intravenous injection showed that using IDM was equally effective in anti-edema effect. After intravenous 20mg/kg2 hours to inflammatory agents,
it resulted in an anti-edema effect. In mustard paste (Mustarol) induced edema, the IDM inhibited edema after 7 days of application. Using this herb (snake slough) extract took six days, but
it is the same as using phenylbutazone; there was no persistent anti-edema effect.
3. For vascular hyperpermeability inhibition: dose of 100mg/kg taken orally can inhibit the dextran-induced skin edema. The herb inhibition rate was 60% (P <0.02).
For the control group using drug IDM10mg/kg, the inhibition rate was 37.5% (P <0.01). The inhibition rate of the spread of pigment extract only was 15% (P <0.05), Using IDM, the inhibition rate was 72.6% (P <0.01), This indicates
a different mechanism of action of the two drugs.(she tui and IDM).
4. The thermal hemolysis of red blood cells inhibitory effect of the extract of 4mg and 12mg was 20.5% (P <0.01) and 48% (P <0.01). That was equivalent to IDM1mg, phenylbutazone
or 5mg hemolysis inhibition. 藥理﹕ 1．抗炎症作用：採用煮沸的蛇蛻水提取物，凍干後得黃褐色粉末，得率為5.4%。用消炎痛（Indomethacin，IDM）、保秦松（Phenylbutazone，PB）作為對照藥物。動物採用雄性大鼠（200-300g體重）和 Dd系雄性小鼠（20g）。飼料、水自由攝取。實驗結果表明： 1.1.急性毒性試驗無明顯的毒性。 1.2.對白血球游走的抑制作用表明：提取液20mg/kg靜脈注射，抑制率約 51.1%（P<0.01），每天口服200mg/kg，5天抑制率為33.7%（P<0.02）。
2．對足跖浮腫的抑制作用：對角叉菜膠所致浮腫的抑制作用，口服無效。50mg/kg皮下注射和20mg/kg靜脈注射呈現與 IDM同等顯著的抗浮腫作用。給發炎劑後，靜脈注射20mg/kg2小時後出現明顯的抗浮腫作用。對芥末糊（Mustarol）所致浮腫的抑制作用，IDM在7天後有抑制浮腫的作用。蛇蛻提取液從第6天開始有效，但與保泰鬆一樣都無持續抗浮腫作用。
3．對血管通透性亢進的抑制作用：劑量為100mg/kg口服對葡聚糖所致皮膚浮腫抑制率 60%（P<0.02）。口服對照藥物 IDM10mg/kg抑制率為37.5%（P<0.01），但對色素擴散的抑制率，提取液僅為15%（P<0.05），IDM則為72.6%（P<0.01），這表明兩種藥物的作用機理不同。
4．對紅血球熱溶血的抑制作用：提取液4mg和12mg的抑制作用分別為20.5%（P<0.01）和48%（P<0.01）；相當於IDM1mg，保泰鬆 5mg 對溶血的抑制作用。
| Actions & Indications: 主治﹕ | Being used in infantile convulsion, spasm, incipient cataract, throat inflammation, boils, itchy skin, 用於小兒驚風，抽搐痙攣，翳障，喉痺，疔腫 ，湯傷，皮膚瘙痒。 | Chemical ingredients: 化學成份﹕ | | The slough of Natrix piscator contains: | 漁游蛇的蛇蛻含： | | collagen | 骨膠原 | | amino acids | 氨基酸 | | glycogen | 糖原 | | nucleic acid | 核酸 | | aminopeptidase | 氨肽酶 | | β-glucuronidase | β-葡萄糖醛酸酶 | | lactate dehydrogenase | 乳酸脫氫酶 | | isocitrate dehydrogenase | 異檸檬酸脫氫酶 | | di- & triphosphopyridine nucleotide diaphorase | 二及三磷酸吡啶核苷酸黃遞酶 | | esterase | 酯酶 | | glucose -6-- phosphate dehydrogenase | 葡萄糖-6-磷酸脫氫酶 | | phosphorylase | 磷酸化 酶 |
| Daily Dosage: 每日用量﹕ | 2 to 3 g in decoction. or make into powder and swallow: 0.3 to 0.6 g 2～3 g；研末吞服 0.3～0.6 g | Samples of formulae: 處方舉例﹕ | For treatment of urination difficulty: Name of formula: yu long san (jade dragan powder) Composition: yu zan hua 6 g, she tui 6 g, ding xiang 3 g. Make into powder. Use 3 g each time. Stir with rice wine. Take orally.
治小便不通：
藥方名：玉龍散《醫學指南》 組成：玉簪花、蛇 蛻各二錢，丁香一錢。 共為末，每服一錢，酒調送下。 | Modern Research: 現代研究﹕ | | Toxicity & Cautions: 毒素與禁忌﹕ | Not to use during pregnancy. 孕婦忌用。 |
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