The following is a snap shot of the page by Google.com :

 NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
                           4-DIMETHYLAMINOANTIPYRINE


-IDENTIFIERS
 ===========

*CATALOG ID NUMBER: 001143

*CAS NUMBER: 58-15-1

*BASE CHEMICAL NAME: DIMETHYLAMINOANTIPYRINE,4-

*PRIMARY NAME: 4-DIMETHYLAMINOANTIPYRINE

*CHEMICAL FORMULA: C₁₃H₁₇N_3O

*STRUCTURAL FORMULA: Not printable

*WLN: T5NNVJ A1 BR& DN1&1 E1

*SYNONYMS:
  AMIDOPYRINE
  DIMETHYLAMINOANTIPYRINE
  AMINOPYRINE
  4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE
  4-DIMETHYLAMINOPHENAZONE
  4-(DIMETHYLAMINO)-1,2-DIHYDRO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE
  1-PHENYL-2,3-DIMETHYL-4-DIMETHYLAMINOPYRAZOLONE-5
  P-DIMETHYLAMINOANTIPYRINE
  AMIDAZOFEN
  AMIDAZOPHEN
  AMIDAZOPHENE
  AMIDOFEBRIN
  AMIDOFEN
  AMIDOPHEN
  AMIDOPHENAZONE
  AMIDOPYRAZOLINE
  AMIDOPYRIN
  AMINOPHENAZONE
  ANAFEBRINA
  BRUFANEUXOL
  DAP
  DEREUMA
  DIMAPYRIN
  DIMETHYLAMINOANALGESINE
  DIMETHYLAMINOAZOPHENE
  4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE
  DIMETHYLAMINOPHENAZONE
  DIMETHYLAMINOPHENYLDIMETHYLPYRAZOLIN
  DIMETHYLAMINOPHENYLDIMETHYLPYRAZOLONE
  4-DIMETHYLAMINO-1-PHENYL-2,3-DIMETHYLPYRAZOLONE
  1,5-DIMETHYL-4-DIMETHYLAMINO-2-PHENYL-3-PYRAZOLONE
  2,3-DIMETHYL-4-DIMETHYLAMINO-1-PHENYL-5-PYRAZOLONE
  DIPIRIN
  DIPYRIN
  DIPYRINE
  FEBRININA
  FEBRON
  ITAMIDONE
  3-KETO-1,5-DIMETHYL-4-DIMETHYLAMINO-2-PHENYL-2,3-DIHYDROPYRAZOLE
  MAMALLET-A
  NETSUSARIN
  NOVAMIDON
  1-PHENYL-2,3-DIMETHYL-4-DIMETHYLAMINOPYRAZOL-5-ONE
  PIRAMIDON
  PIRIDOL
  PIROMIDINA
  POLINALIN
  PYRADONE
  PYRAMIDON
  PYRAMIDONE


-PHYSICAL CHEMICAL DATA
 ======================

*PHYSICAL DESCRIPTION: LITERATURE: Small colorless crystals or white crystalline
                                    powder
                       REPOSITORY: White powder

*MOLECULAR WEIGHT: 231.30

*SPECIFIC GRAVITY: Not available

*DENSITY: Not available

*MP (DEG C): 107-109 C [031,042]

*BP (DEG C): Not available

*SOLUBILITIES:
       WATER : >=100 mg/mL @ 22 C (RAD)

        DMSO : >=100 mg/mL @ 22 C (RAD)

 95% ETHANOL : >=100 mg/mL @ 22 C (RAD)

    METHANOL : Not available

     ACETONE : >=100 mg/mL @ 22 C (RAD)

     TOLUENE : Not available

 OTHER SOLVENTS:
  Alcohol: 1 g/1.5 mL [031]
  Benzene: 1 g/12 mL [031]
  Chloroform: 1 g/1 mL [031]
  Ether: 1 g/13 mL [031]

*VOLATILITY:
    Vapor pressure: Not available
    Vapor density : Not available

*FLAMMABILITY(FLASH POINT):
      Flash point data for this chemical are not available; however, it is
 probably combustible.  Fires involving this material can be controlled with
 a dry chemical, carbon dioxide or Halon extinguisher.

*UEL: Not available                         LEL: Not available

*REACTIVITY:
      This chemical is readily attacked by mild oxidizing agents in the
 presence of water [031].  It is incompatible with acacia, apomorphine,
 aspirin, chloral hydrate, iodine and tannic acid [295].

*STABILITY:
      This chemical is sensitive to exposure to light [031,295].  UV spectro-
 photometric stability screening indicates that solutions of this chemical in
 water are stable for at least 24 hours (RAD).

*OTHER PHYSICAL DATA:
  Melting point also reported as 134-135 C [016,047]
  Solubility in water is increased by the addition of sodium benzoate [031]
  Aqueous solution is slightly alkaline to litmus [031]
  pH (5% water solution): 7.5-9 [295]
  Odorless [295]
  Slightly bitter taste [295]


-TOXICITY
 ========

*NIOSH REGISTRY NUMBER: CD2625000

*TOXICITY:
        typ. dose    mode     specie      amount     units     other
          LD50       ims       mus          306      mg/kg
          LD50       ims       rat          340      mg/kg
          LD50       ipr       ham          380      mg/kg
          LD50       ipr       mam          300      mg/kg
          LD50       ipr       mus          169      mg/kg
          LD50       ipr       rat          190      mg/kg
          LDLo       ivn       cat          100      mg/kg
          LD50       ivn       dog          121      mg/kg
          LD50       ivn       gpg          130      mg/kg
          LD50       ivn       mus           78      mg/kg
          LD50       ivn       rat           98      mg/kg
          LD50       ivn       rbt           80      mg/kg
          LDLo       orl       cat          100      mg/kg
          LD50       orl       dog          220      mg/kg
          LD50       orl       gpg          910      mg/kg
          LD50       orl       mus          350      mg/kg
          LD50       orl       rat          600      mg/kg
          LD50       orl       rbt          600      mg/kg
          LDLo       par       frg          900      mg/kg
          LDLo       scu       gpg          250      mg/kg
          LD50       scu       mus          248      mg/kg
          LD50       scu       rat          295      mg/kg
          LDLo       scu       rbt          250      mg/kg
          LDLo       unr       man          220      mg/kg
          LDLo       unr       mus          225      mg/kg

*AQTX/TLM96: Not available

*SAX TOXICITY EVALUATION:
  THR: Human poison by unspecified route.  Experimental poison by ingestion,
       subcutaneous, intramuscular, intravenous, implant and possibly other
       routes.  Moderately toxic by parenteral route.  An experimental tera-
       togen.  Experimental reproductive effects.  Mutation data.  Mixed with
       NaNO2 (1:1), it is an experimental carcinogen.

*CARCINOGENICITY: Not available

*MUTATION DATA:
       test          lowest dose      |      test          lowest dose
    -----------   -----------------   |   -----------   -----------------
    cyt-ham:fbr        3 mmol/L       |   dni-mus:oth      100 mg/L
    dnr-esc         1250 ug/well      |   msc-ham-orl      100 mg/kg
    mma-sat           31 umol/plate   |   otr-ham-orl      100 mg/kg
    otr-rat-orl     2520 mg/kg/6W     |

*TERATOGENICITY:
  Reproductive Effects Data:
    TDLo: orl-mus     60 mg/kg (7-12D preg)
    TDLo: orl-mus    900 mg/kg (7-12D preg)
    TDLo: orl-rat     60 mg/kg (9-14D preg)
    TDLo: orl-rat    900 mg/kg (9-14D preg)
    TDLo: scu-mus    630 mg/kg (9-11D preg)
    TDLo: scu-mus    600 mg/kg (7-9D preg)

*STANDARDS, REGULATIONS & RECOMMENDATIONS:
  OSHA: None
  ACGIH: None
  NIOSH Criteria Document: None
  NFPA Hazard Rating: Health (H): None
                      Flammability (F): None
                      Reactivity (R): None

*OTHER TOXICITY DATA:
  Status: EPA Genetox Program 1988, Negative: In vitro SCE-nonhuman
          EPA TSCA Chemical Inventory, 1986
          EPA TSCA Test Submission (TSCATS) Data Base, June 1989
          Meets criteria for proposed OSHA Medical Records Rule


-OTHER DATA (Regulatory)
 =======================

*PROPER SHIPPING NAME (IATA): Not restricted

*UN/ID NUMBER:

*HAZARD CLASS:               SUBSIDIARY RISK:         PACKING GROUP:

*LABELS REQUIRED:

*PACKAGING: PASSENGER: PKG. INSTR.:                 MAXIMUM QUANTITY:
            CARGO    : PKG. INSTR.:                 MAXIMUM QUANTITY:

*SPECIAL PROVISIONS:

*USES:
      This chemical is used in human and veterinary medicine as an antipyretic,
 analgesic and anti-inflammatory agent.  It is also sometimes used in drug meta-
 bolism.  It is also used as a tranquilizer.

*COMMENTS:
      Clinical use of this compound has been sharply curtailed due to its
 potentially fatal bone-marrow toxicity [406].


-HANDLING PROCEDURES
 ===================

*ACUTE/CHRONIC HAZARDS:
      When heated to decomposition this compound emits toxic fumes of nitrogen
 oxides [043].

*MINIMUM PROTECTIVE CLOTHING: Not available

*RECOMMENDED GLOVE MATERIALS:
 GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
      This chemical has not been tested for permeation by Radian Corporation;
 however, the GlovES+ expert system was used to extrapolate permeation test
 information from compounds in the same chemical class.  The GlovES+ system uses
 permeation data from literature sources; therefore, extra safety margins should
 be used with the estimated protection time(s).  If this chemical makes direct
 contact with your glove, or if a tear, puncture or hole develops, replace them
 at once.
      The GlovES+ expert system is a tool that can help people better manage
 protection from chemicals, however this tool cannot replace sound judgment nor
 make technical decisions.  Our GlovES+ expert system is designed to offer
 initial advice and assistance in glove selection while the final glove
 selection should be made by knowledgeable individuals based on the specific
 circumstances involved.

 Glove Type            Model Number      Thickness   Estimated Protection Time
 PVA                   Edmont 25-545      0.07 mm            240 min
 Nitrile               Edmont 37-155      0.40 mm            240 min
 Viton                 North F-091        0.24 mm            240 min

*RECOMMENDED RESPIRATOR:
      Where the neat test chemical is weighed and diluted, wear a NIOSH-
 approved half face respirator equipped with an organic vapor/acid gas
 cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
 dust/mist filter.

*OTHER: Not available

*STORAGE PRECAUTIONS:
      You should protect this material from exposure to light, and store
 it in a refrigerator.

*SPILLS AND LEAKAGE:
      If you spill this chemical, you should dampen the solid spill material
 with water, then transfer the dampened material to a suitable container.  Use
 absorbent paper dampened with water to pick up any remaining material.  Seal
 your contaminated clothing and the absorbent paper in a vapor-tight plastic
 bag for eventual disposal.  Wash all contaminated surfaces with a soap
 and water solution.  Do not reenter the contaminated area until the Safety
 Officer (or other responsible person) has verified that the area has been
 properly cleaned.

*DISPOSAL AND WASTE TREATMENT: Not available


-EMERGENCY PROCEDURES
 ====================

*SKIN CONTACT:
      IMMEDIATELY flood affected skin with water while removing and isolating
 all contaminated clothing.  Gently wash all affected skin areas thoroughly
 with soap and water.
      If symptoms such as redness or irritation develop, IMMEDIATELY call a
 physician and be prepared to transport the victim to a hospital for treatment.

*INHALATION:
      IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
 If symptoms (such as wheezing, coughing, shortness of breath, or burning in
 the mouth, throat, or chest) develop, call a physician and be prepared to
 transport the victim to a hospital.
      Provide proper respiratory protection to rescuers entering an unknown
 atmosphere.  Whenever possible, Self-Contained Breathing Apparatus (SCBA)
 should be used; if not available, use a level of protection greater than or
 equal to that advised under Respirator Recommendation.

*EYE CONTACT:
      First check the victim for contact lenses and remove if present.  Flush
 victim's eyes with water or normal saline solution for 20 to 30 minutes while
 simultaneously calling a hospital or poison control center.
      Do not put any ointments, oils, or medication in the victim's eyes without
 specific instructions from a physician.
      IMMEDIATELY transport the victim after flushing eyes to a hospital even if
 no symptoms (such as redness or irritation) develop.

*INGESTION:
      DO NOT INDUCE VOMITING.  If the victim is conscious and not convulsing,
 give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
 hospital or poison control center.  Be prepared to transport the victim to a
 hospital if advised by a physician.
      If the victim is convulsing or unconscious, do not give anything by mouth,
 ensure that the victim's airway is open and lay the victim on his/her side with
 the head lower than the body.  DO NOT INDUCE VOMITING.  IMMEDIATELY transport
 the victim to a hospital.

*SYMPTOMS:
      Symptoms of exposure to this compound include allergic reactions, strong
 spasmolytic effect on smooth muscle of peripheral blood vessels, irritability,
 palsy, copious sweating, dilated pupils, sharp drop then rise in body tempera-
 ture, dysuria, dyspnea, anxiety, tenesmus, urinary frequency, intermittent
 fever, fatty infiltration of the liver, heart muscle degeneration and death
 due to circulatory failure following cardiovascular collapse [151].  Agranulo-
 cytosis often occurs [031,295,301,406].  Ingestion may cause central nervous
 system stimulation, vomiting, convulsions, cyanosis, tinnitus, leukopenia,
 kidney damage and coma [151,301].  Ingestion may also lead to nausea, mental
 disturbances, methemoglobinemia, chocolate-colored blood, dizziness, epigas-
 tric pain, difficulty in hearing, thready pulse and liver damage [301].  Other
 symptoms reported via ingestion include hemolytic anemia, porphyria and severe
 gastrointestinal bleeding [295].  Bone marrow depression also occurs [043].
 Rare eye effects include acute transient myopia [099].
      Chronic symptoms include anorexia, edema, oliguria, urticaria, hyper-
 sensitivity, aplastic anemia, sore throat, fever, pharygeal membrane, jaundice,
 enlargement of the liver and spleen, exfoliative dermatitis, gastric or duo-
 denal erosion with perforation or bleeding, adrenal necrosis, thrombocytopenic
 purpura and acute leukemia [301].


-SOURCES
 =======

*SOURCES:
 [015] Lewis, R.J., Sr. and R.L. Tatken, Eds.  Registry of Toxic Effects
          of Chemical Substances.  On-line Ed.  National Institute for
          Occupational Safety and Health.  Cincinnati, OH.  CD2625000.
          September 19, 1989.

 [016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds.  CRC Handbook
          of Chemistry and Physics.  70th Ed.  CRC Press, Inc.  Boca Raton,
          FL.  1989.  p. C-86, #1334.

 [031] Windholz, M., Ed.  The Merck Index.  10th Ed.  Merck and Co.
          Rahway, NJ.  1983.  p. 71, #480.

 [043] Sax, N.I. and Richard J. Lewis, Sr.  Dangerous Properties of Industrial
          Materials.  7th Ed.  Van Nostrand Reinhold.  New York.  1989.
          Vol. II, p. 1338, #DOT000.

 [047] Weast, R.C. and M.J. Astle, Eds.  CRC Handbook of Data on
          Organic Compounds.  CRC Press, Inc.  Boca Raton, FL.
          1985.  Vol. I, p. 111, #A01953.

 [082] U.S. Environmental Protection Agency, Office of Toxic Substances.
          Toxic Substances Control Act Chemical Substance Inventory:  1985
          Edition.  5 Vols.  U.S. Environmental Protection Agency.
          Washington, D.C.  January 1986.  Listed.

 [099] Grant, W. Morton, M.D.  Toxicology of the Eye.  3rd Ed.  Charles
          C. Thomas, Publisher.  Springfield, IL.  1986.  p. 78.

 [107] Occupational Health Services, Inc.  Hazardline.  Occupational
          Health Services, Inc.  New York.  Listed.

 [110] Oak Ridge National Laboratory.  Environmental Mutagen Information
          Center (EMIC), Bibliographic Data Base.  Oak Ridge National
          Laboratory.  Oak Ridge, TN.  Listed.

 [120] Oak Ridge National Laboratory.  Environmental Teratogen Information
          Center (ETIC), Bibliographic Data Base.  Oak Ridge National
          Laboratory.  Oak Ridge, TN.  Listed.

 [151] Gosselin, R.E., H.C. Hodge, and R.P. Smith.  Clinical Toxicology
          of Commercial Products.  5th Ed.  Williams and Wilkins, Co.
          Baltimore.  1984.  p. II-395, #1570.

 [205] Dean, John A., Ed.  Lange's Handbook of Chemistry.  13th Ed.
          McGraw-Hill Book Company.  New York.  1985.  p. 7-334, #d911.

 [275] Aldrich Chemical Company.  Aldrich Catalog/Handbook of Fine
          Chemical.  Aldrich Chemical Co., Inc.  Milwaukee, WI.
          1988.  p. 582, #D13,910-6.

 [295] Reynolds, James E.F., Ed.  Martindale The Extra Pharmacopoeia.  28th Ed.
          The Pharmaceutical Press.  London.  1982.  pp. 245-246.

 [301] Dreisbach, R.H.  Handbook of Poisoning: Prevention, Diagnosis
          and Treatment.  11th Ed.  Lange Medical Publications.  Los
          Altos, CA.  1983.  pp. 332-334.

 [406] Goodman, L.S., A. Gilman, F. Murad and T.W. Rall, Eds.  The
          Pharmacological Basis of Therapeutics.  7th Ed.  Macmillan
          Publishing Co.  New York.  1985.  pp. 690-692.

 [455] The Pharmaceutical Society of Great Britain.  The Pharmaceutical Codex.
          11th Edition.  The Pharmaceutical Press.  London.  1979.  p. 543.

 [610] Clansky, Kenneth B., Ed.  Suspect Chemicals Sourcebook:  A Guide to
          Industrial Chemicals Covered Under Major Federal Regulatory and
          Advisory Programs.  Roytech Publications, Inc.  Burlingame, CA.
          1990.  Not listed.

 [620] United States National Toxicology Program.  Chemical Status Report.
          NTP Chemtrack System.  Research Triangle Park, NC.  November 6, 1990.
          Not listed.
 

Sponsors' Ads by Google 以下為谷歌所提供贊助者之廣告